GPCRmd

Protein Information: Smoothened homolog

Cannonical Uniprot Accesion Number: Q99835

        10         20         30         40         50
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR 
        60         70         80         90        100
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE 
       110        120        130        140        150
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT 
       160        170        180        190        200
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT 
       210        220        230        240        250
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA 
       260        270        280        290        300
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT 
       310        320        330        340        350
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY 
       360        370        380        390        400
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR 
       410        420        430        440        450
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML 
       460        470        480        490        500
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT 
       510        520        530        540        550
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC 
       560        570        580        590        600
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV 
       610        620        630        640        650
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE 
       660        670        680        690        700
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST 
       710        720        730        740        750
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP 
       760        770        780        7
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF

Scientific name: Homo sapiens

Is this protein a mutant? False

Alternative names:

Smoothened homolog

Corresponding Cannonical Protein:

Protein ID: 185

You can find this protein in the following complex structures:

Complex Structure ID: 191 Complex Structure ID: 203 Complex Structure ID: 160 Complex Structure ID: 159 Complex Structure ID: 205 Complex Structure ID: 206 Complex Structure ID: 200 Complex Structure ID: 248 Complex Structure ID: 207 Complex Structure ID: 412 Complex Structure ID: 439 Complex Structure ID: 453 Complex Structure ID: 531 Complex Structure ID: 632 Complex Structure ID: 652 Complex Structure ID: 754 Complex Structure ID: 805 Complex Structure ID: 785 Complex Structure ID: 837 Complex Structure ID: 946 Complex Structure ID: 191 Complex Structure ID: 205 Complex Structure ID: 207

References in which this protein is mentioned:

The UniProt Consortium. 2014. UniProt: a hub for protein information. Nucleic Acids Research 43 (None). doi: https://doi.org/10.1093/nar/gku989. Available in: Pubmed Link

Kozielewicz P, Turku A, Bowin C-F, Petersen J, Valnohova J, Consuelo Alonso Cañizal M, Ono Y, Inoue A, Hoffmann C, Schulte G. 2020. Structural insight into small molecule action on Frizzleds. Nature communications 1 (11). doi: 10.1038/s41467-019-14149-3. Available in: Pubmed Link

Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, et al.. 2020. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature methods 17 (8). doi: 10.1038/s41592-020-0884-y. Available in: Pubmed Link

Ainoleena Turku; Hannes Schihada; Pawel Kozielewicz; Carl-Fredrik Bowin; Gunnar Schulte. 2021. Residue 6.43 defines receptor function in class F GPCRs. Nature communications 12 (1). doi: 10.1038/s41467-021-24004-z. Available in: Pubmed Link