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Protein Information: D(2) dopamine receptor

Cannonical Uniprot Accesion Number: P14416

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRSQQKEKKA TQMLAIVLGV FIICWLPFFI 
       260        270        280        290        300
THILNIHCDC NIPPVLYSAF TWLGYVNSAV NPIIYTTFNI EFRKAFLKIL 
   
HC

Scientific name: Homo sapiens


Is this protein a mutant? True


Mutations:


Residue 223: From V to -

Residue 224: From N to -

Residue 225: From T to -

Residue 226: From K to -

Residue 227: From R to -

Residue 228: From S to -

Residue 229: From S to -

Residue 230: From R to -

Residue 231: From A to -

Residue 232: From F to -

Residue 233: From R to -

Residue 234: From A to -

Residue 235: From H to -

Residue 236: From L to -

Residue 237: From R to -

Residue 238: From A to -

Residue 239: From P to -

Residue 240: From L to -

Residue 241: From K to -

Residue 242: From G to -

Residue 243: From N to -

Residue 244: From C to -

Residue 245: From T to -

Residue 246: From H to -

Residue 247: From P to -

Residue 248: From E to -

Residue 249: From D to -

Residue 250: From M to -

Residue 251: From K to -

Residue 252: From L to -

Residue 253: From C to -

Residue 254: From T to -

Residue 255: From V to -

Residue 256: From I to -

Residue 257: From M to -

Residue 258: From K to -

Residue 259: From S to -

Residue 260: From N to -

Residue 261: From G to -

Residue 262: From S to -

Residue 263: From F to -

Residue 264: From P to -

Residue 265: From V to -

Residue 266: From N to -

Residue 267: From R to -

Residue 268: From R to -

Residue 269: From R to -

Residue 270: From V to -

Residue 271: From E to -

Residue 272: From A to -

Residue 273: From A to -

Residue 274: From R to -

Residue 275: From R to -

Residue 276: From A to -

Residue 277: From Q to -

Residue 278: From E to -

Residue 279: From L to -

Residue 280: From E to -

Residue 281: From M to -

Residue 282: From E to -

Residue 283: From M to -

Residue 284: From L to -

Residue 285: From S to -

Residue 286: From S to -

Residue 287: From T to -

Residue 288: From S to -

Residue 289: From P to -

Residue 290: From P to -

Residue 291: From E to -

Residue 292: From R to -

Residue 293: From T to -

Residue 294: From R to -

Residue 295: From Y to -

Residue 296: From S to -

Residue 297: From P to -

Residue 298: From I to -

Residue 299: From P to -

Residue 300: From P to -

Residue 301: From S to -

Residue 302: From H to -

Residue 303: From H to -

Residue 304: From Q to -

Residue 305: From L to -

Residue 306: From T to -

Residue 307: From L to -

Residue 308: From P to -

Residue 309: From D to -

Residue 310: From P to -

Residue 311: From S to -

Residue 312: From H to -

Residue 313: From H to -

Residue 314: From G to -

Residue 315: From L to -

Residue 316: From H to -

Residue 317: From S to -

Residue 318: From T to -

Residue 319: From P to -

Residue 320: From D to -

Residue 321: From S to -

Residue 322: From P to -

Residue 323: From A to -

Residue 324: From K to -

Residue 325: From P to -

Residue 326: From E to -

Residue 327: From K to -

Residue 328: From N to -

Residue 329: From G to -

Residue 330: From H to -

Residue 331: From A to -

Residue 332: From K to -

Residue 333: From D to -

Residue 334: From H to -

Residue 335: From P to -

Residue 336: From K to -

Residue 337: From I to -

Residue 338: From A to -

Residue 339: From K to -

Residue 340: From I to -

Residue 341: From F to -

Residue 342: From E to -

Residue 343: From I to -

Residue 344: From Q to -

Residue 345: From T to -

Residue 346: From M to -

Residue 347: From P to -

Residue 348: From N to -

Residue 349: From G to -

Residue 350: From K to -

Residue 351: From T to -

Residue 352: From R to -

Residue 353: From T to -

Residue 354: From S to -

Residue 355: From L to -

Residue 356: From K to -

Residue 357: From T to -

Residue 358: From M to -

Residue 359: From S to -

Residue 360: From R to -

Residue 361: From R to -

Residue 362: From K to -

Residue 363: From L to -

Alternative names:


  • Dopamine D2 receptor


Corresponding Cannonical Protein:


Protein ID: 90

You can find this protein in the following complex structures:


Complex Structure ID: 1256

References in which this protein is mentioned:


Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Maria Hauge Pedersen, Brian Medel-Lacruz, Maria-Florencia Angelo, Sandrine Villette, Pierre Van Delft, Laetitia Fouillen, Sébastien Mongrand, Jana Selent, Tarson Tolentino-Cortez, Gabriel Barreda-Gómez, Stéphane Grégoire, Elodie Masson, Thierry Durroux, Jonathan A. Javitch, Ramon Guixà-González, Isabel D. Alves, Pierre Trifilieff. 2023. Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular Psychiatry (). doi: 10.1038/s41380-022-01928-6. Available in: Pubmed Link

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ERNEST (COST Action CA18133)

GLISTEN (COST Action CM1207)

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