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Publications

Bous, Julien and Kinsolving, Julia and Gratz, Lukas and Scharf, Magdalena M. and Voss, Jan Hendrik and Selcuk, Berkay and Adebali, Ogun and Schulte, Gunnar. 2024. Structural basis of frizzled 7 activation and allosteric regulation. Nature Communications 15 (1). doi: 10.1038/s41467-024-51664-4. (http://dx.doi.org/10.1038/s41467-024-51664-4)


Receptor Uniprot entry name Uniprot ID Family Class PDB ID State Species Model type Ligand(s) Model name Num. of atoms Membrane composition Accum. sim. time (µs) Software Force field Submitted by
Frizzled-7 fzd7_human O75084 Frizzled F 9EW2 None Homo sapiens Apoform FZD7 in active conformation (Homo) 65088 POPC Y01 1.80 Gromacs 2023-2 CHARMM 36m Julien Bous, Karolinsk Institutet Report
Frizzled-7 fzd7_human O75084 Frizzled F 9EPO None Homo sapiens Apoform FZD7 in inactive conformation (Homo) 64511 POPC Y01 1.80 Gromacs 2023-2 CHARMM 36m Julien Bous, Karolinsk Institutet Report

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