Publications
Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A. Lambert, David E. Gloriam, Gunnar Schulte. 2023. Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nature Communications 14. doi: https://doi.org/10.1038/s41467-023-40213-0. (https://www.nature.com/articles/s41467-023-40213-0)
| Receptor | Uniprot entry name | Uniprot ID | Family | Class | PDB ID | State | Species | Model type | Ligand(s) | Model name | Num. of atoms | Membrane composition | Accum. sim. time (µs) | Software | Force field | Submitted by | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) Y470A | 74359 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) Y278A | 74428 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) L419A | 74520 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) G422A | 74466 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) C277A | 74504 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) W520A | 74517 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) R449A | 74804 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report | |
| View | Frizzled-5 | fzd5_human | Q13467 | Frizzled | F | Homo | None | Homo sapiens | Apoform | FZD5 (G180-C539) wt | 74487 | POPC | 1.50 | GROMACS 2021.3 | CHARMM 36m | Magdalena Scharf, Karolinska Institute | Report |
