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Publications

Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A. Lambert, David E. Gloriam, Gunnar Schulte. 2023. Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nature Communications 14. doi: https://doi.org/10.1038/s41467-023-40213-0. (https://www.nature.com/articles/s41467-023-40213-0)


Receptor Uniprot entry name Uniprot ID Family Class PDB ID State Species Model type Ligand(s) Model name Num. of atoms Membrane composition Accum. sim. time (µs) Software Force field Submitted by
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) wt 74487 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) R449A 74804 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) W520A 74517 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) C277A 74504 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) G422A 74466 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) L419A 74520 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) Y278A 74428 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report
Frizzled-5 fzd5_human Q13467 Frizzled F Homo None Homo sapiens Apoform FZD5 (G180-C539) Y470A 74359 POPC 1.50 GROMACS 2021.3 CHARMM 36m Magdalena Scharf, Karolinska Institute Report

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