GPCRmd

Protein Information: G-protein coupled bile acid receptor 1

Cannonical Uniprot Accesion Number: Q8TDU6

        10         20         30         40         50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA 
        60         70         80         90        100
GCFFLSLLLA GLLTGLALPT LPGLANQSRR GYWSCLLVYL APNFSFLSLL 
       110        120        130        140        150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT 
       160        170        180        190        200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC 
       210        220        230        240        250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA 
       260        270        280        290        300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ 
       310        320        330  
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN

Scientific name: Homo sapiens

Is this protein a mutant? True

Mutations:

Residue 75: From W to A

Alternative names:

BG37
GPBA
G-protein coupled receptor GPCR19
hBG37
hGPCR19
M-BAR
Membrane-type receptor for bile acids
TGR5

Corresponding Cannonical Protein:

Protein ID: 122

You can find this protein in the following complex structures:

Complex Structure ID: 2012

References in which this protein is mentioned:

Papadopoulos, M. Giovanna E. and Perhal, Alexander F. and Medel-Lacruz, Brian and Ladurner, Angela and Selent, Jana and Dirsch, Verena M. and Kolb, Peter. 2024. Discovery and characterization of small-molecule TGR5 ligands with agonistic activity. European Journal of Medicinal Chemistry None (None). doi: 10.1016/j.ejmech.2024.116616. Available in: Pubmed Link