Protein Information: Smoothened homolog
Cannonical Uniprot Accesion Number: Q99835
10 20 30 40 50 MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR 60 70 80 90 100 SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE 110 120 130 140 150 EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT 160 170 180 190 200 RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT 210 220 230 240 250 DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA 260 270 280 290 300 TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT 310 320 330 340 350 MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY 360 370 380 390 400 QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR 410 420 430 440 450 AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML 460 470 480 490 500 RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT 510 520 530 540 550 KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC 560 570 580 590 600 RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV 610 620 630 640 650 AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE 660 670 680 690 700 QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST 710 720 730 740 750 IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP 760 770 780 7 SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF
Scientific name: Homo sapiens
Is this protein a mutant? False
Alternative names:
Smoothened homolog
Corresponding Cannonical Protein:
Protein ID: 185
You can find this protein in the following complex structures:
Complex Structure ID: 191 Complex Structure ID: 203 Complex Structure ID: 160 Complex Structure ID: 159 Complex Structure ID: 205 Complex Structure ID: 206 Complex Structure ID: 200 Complex Structure ID: 248 Complex Structure ID: 207 Complex Structure ID: 412 Complex Structure ID: 439 Complex Structure ID: 453 Complex Structure ID: 531 Complex Structure ID: 632 Complex Structure ID: 652 Complex Structure ID: 754 Complex Structure ID: 805 Complex Structure ID: 785 Complex Structure ID: 837 Complex Structure ID: 946 Complex Structure ID: 191 Complex Structure ID: 205 Complex Structure ID: 207
References in which this protein is mentioned:
The UniProt Consortium. 2014. UniProt: a hub for protein information. Nucleic Acids Research 43 (None). doi: https://doi.org/10.1093/nar/gku989. Available in: Pubmed Link
Kozielewicz P, Turku A, Bowin C-F, Petersen J, Valnohova J, Consuelo Alonso Cañizal M, Ono Y, Inoue A, Hoffmann C, Schulte G. 2020. Structural insight into small molecule action on Frizzleds. Nature communications 1 (11). doi: 10.1038/s41467-019-14149-3. Available in: Pubmed Link
Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, et al.. 2020. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature methods 17 (8). doi: 10.1038/s41592-020-0884-y. Available in: Pubmed Link
Ainoleena Turku; Hannes Schihada; Pawel Kozielewicz; Carl-Fredrik Bowin; Gunnar Schulte. 2021. Residue 6.43 defines receptor function in class F GPCRs. Nature communications 12 (1). doi: 10.1038/s41467-021-24004-z. Available in: Pubmed Link