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Protein Information: Frizzled-5

Cannonical Uniprot Accesion Number: Q13467

        10         20         30         40         50
MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH 
        60         70         80         90        100
MPNQFNHDTQ DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK 
       110        120        130        140        150
PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG RDAEVLCMDY 
       160        170        180        190        200
NRSEATTAPP RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL 
       210        220        230        240        250
KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG LWSVLCFIST 
       260        270        280        290        300
STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 
       310        320        330        340        350
EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN 
       360        370        380        390        400
EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL 
       410        420        430        440        450
RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIAI 
       460        470        480        490        500
GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGHD TGQPRAKPEY 
       510        520        530        540        550
WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR PRRGHKSGGA 
       560        570        580       
MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV

Scientific name: Homo sapiens


Is this protein a mutant? True


Mutations:


Residue 449: From R to A

Alternative names:


  • Fz-5

  • FzE5

  • hFz5


Corresponding Cannonical Protein:


Protein ID: 1243

You can find this protein in the following complex structures:


Complex Structure ID: 1278

References in which this protein is mentioned:


. None. . (). doi: Graetz-et-al. Available in: Pubmed Link

Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A. Lambert, David E. Gloriam, Gunnar Schulte. 2023. Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nature Communications 14 (). doi: https://doi.org/10.1038/s41467-023-40213-0. Available in: Pubmed Link

SUPPORTED BY

ERNEST (COST Action CA18133)

GLISTEN (COST Action CM1207)

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