GPCRmd

Molecule Info: cholesterol

Smiles:
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

InChIKey:
HVYWMOMLDIMFJA-DPAQBDIFSA-N

InChI:

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChIcol:
1

More information (from its Standard Form):

cholesterol

Complex structures in which this molecule appears :

References in which this molecule is mentioned:

Grimes, Jak and Koszegi, Zsombor and Lanoiselee, Yann and Miljus, Tamara and O'Brien, Shannon L. and Stepniewski, Tomasz M. and Medel-Lacruz, Brian and Baidya, Mithu and Makarova, Maria and Mistry, Ravi and Goulding, Joelle and Drube, Julia and Hoffmann, Carsten and Owen, Dylan M. and Shukla, Arun K. and Selent, Jana and Hill, Stephen J. and Calebiro, Davide. 2023. Plasma membrane preassociation drives β-arrestin coupling to receptors and activation. Cell 186 (10). doi: 10.1016/j.cell.2023.04.018.

Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Maria Hauge Pedersen, Brian Medel-Lacruz, Maria-Florencia Angelo, Sandrine Villette, Pierre Van Delft, Laetitia Fouillen, Sébastien Mongrand, Jana Selent, Tarson Tolentino-Cortez, Gabriel Barreda-Gómez, Stéphane Grégoire, Elodie Masson, Thierry Durroux, Jonathan A. Javitch, Ramon Guixà-González, Isabel D. Alves, Pierre Trifilieff. 2023. Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular Psychiatry (). doi: 10.1038/s41380-022-01928-6.

None. None. None. None None (None). doi: Provo.

Lorenza Pirona, Federico Ballabio, Mercedes Alfonso-Prieto, Riccardo Capelli. 2024. Calcium-Driven In Silico Inactivation of a Human Olfactory Receptor. Journal of Chemical Information and Modeling None (None). doi: 10.1021/acs.jcim.4c00249.

Papadopoulos, M. Giovanna E. and Perhal, Alexander F. and Medel-Lacruz, Brian and Ladurner, Angela and Selent, Jana and Dirsch, Verena M. and Kolb, Peter. 2024. Discovery and characterization of small-molecule TGR5 ligands with agonistic activity. European Journal of Medicinal Chemistry None (None). doi: 10.1016/j.ejmech.2024.116616.

None. None. Location-biased β-arrestin conformations direct G protein-coupled receptor signa. None None (None). doi: spatiotemporalsignaling.

None. None. Location-biased β-arrestin conformations direct G protein-coupled receptor signaling. None None (None). doi: None.

Bous, Julien and Kinsolving, Julia and Gratz, Lukas and Scharf, Magdalena M. and Voss, Jan Hendrik and Selcuk, Berkay and Adebali, Ogun and Schulte, Gunnar. 2024. Structural basis of frizzled 7 activation and allosteric regulation. Nature Communications 15 (1). doi: 10.1038/s41467-024-51664-4.

None. None. Location-biased β-arrestin conformations direct G protein-coupled receptor signa. None None (None). doi: None.

None. None. Location-biased β-arrestin conformations direct G protein-coupled receptor signa.. None None (None). doi: None.

Kumar, G. Aditya and Sarkar, Parijat and Stepniewski, Tomasz Maciej and Jafurulla, Md. and Singh, Shishu Pal and Selent, Jana and Chattopadhyay, Amitabha. 2021. A molecular sensor for cholesterol in the human serotonin 1A receptor. Science Advances 7 (30). doi: 10.1126/sciadv.abh2922.